Full disclosure: Genome assembly is still hard.
Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies...
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Public Library of Science (PLoS)
2018-04-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC5915270?pdf=render |
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doaj-2905281bb5d64303ab917fb3492d75662021-07-02T12:45:59ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852018-04-01164e200589410.1371/journal.pbio.2005894Full disclosure: Genome assembly is still hard.Stephen RichardsTwo recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies-especially challenging in microscopic species with high sequence polymorphism. These exemplars demonstrate the need to go beyond single draft-quality reference genomes to high-quality multiple species comparative genomics if we are to fully capture the value of genomics.http://europepmc.org/articles/PMC5915270?pdf=render |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Stephen Richards |
| spellingShingle |
Stephen Richards Full disclosure: Genome assembly is still hard. PLoS Biology |
| author_facet |
Stephen Richards |
| author_sort |
Stephen Richards |
| title |
Full disclosure: Genome assembly is still hard. |
| title_short |
Full disclosure: Genome assembly is still hard. |
| title_full |
Full disclosure: Genome assembly is still hard. |
| title_fullStr |
Full disclosure: Genome assembly is still hard. |
| title_full_unstemmed |
Full disclosure: Genome assembly is still hard. |
| title_sort |
full disclosure: genome assembly is still hard. |
| publisher |
Public Library of Science (PLoS) |
| series |
PLoS Biology |
| issn |
1544-9173 1545-7885 |
| publishDate |
2018-04-01 |
| description |
Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies-especially challenging in microscopic species with high sequence polymorphism. These exemplars demonstrate the need to go beyond single draft-quality reference genomes to high-quality multiple species comparative genomics if we are to fully capture the value of genomics. |
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http://europepmc.org/articles/PMC5915270?pdf=render |
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AT stephenrichards fulldisclosuregenomeassemblyisstillhard |
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