Formulation of Orally Disintegrating Films as an Amorphous Solid Solution of a Poorly Water-Soluble Drug

Formulation of Orally Disintegrating Films as an Amorphous Solid Solution of a Poorly Water-Soluble Drug

The objective of the present study was to develop an orally disintegrating film (ODF) for a poorly water-soluble drug, phenytoin (PHT), using the cosolvent solubilization technique to achieve the amorphization of the drug, followed by the preparation of ODFs. Eleven formulations were prepared with d...

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Bibliographic Details
Main Authors:	Pattaraporn Panraksa, Pratchaya Tipduangta, Kittisak Jantanasakulwong, Pensak Jantrawut
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	Membranes
Subjects:	phenytoin poorly water-soluble drug orally disintegrating films cosolvent amorphous solid dispersion
Online Access:	https://www.mdpi.com/2077-0375/10/12/376

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