Short and long sleeping mutants reveal links between sleep and macroautophagy

Short and long sleeping mutants reveal links between sleep and macroautophagy

Sleep is a conserved and essential behavior, but its mechanistic and functional underpinnings remain poorly defined. Through unbiased genetic screening in Drosophila, we discovered a novel short-sleep mutant we named argus. Positional cloning and subsequent complementation, CRISPR/Cas9 knock-out, an...

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Bibliographic Details
Main Authors: Joseph L Bedont, Hirofumi Toda, Mi Shi, Christine H Park, Christine Quake, Carly Stein, Anna Kolesnik, Amita Sehgal
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
sleep
autophagy
genetics
Drosophila
argus
blue cheese
Online Access:https://elifesciences.org/articles/64140

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