JZTX-V Targets the Voltage Sensor in Kv4.2 to Inhibit Ito Potassium Channels in Cardiomyocytes

JZTX-V Targets the Voltage Sensor in Kv4.2 to Inhibit Ito Potassium Channels in Cardiomyocytes

Kv4 potassium channels are responsible for transient outward K+ currents in the cardiac action potential (AP). Previous experiments by our group demonstrated that Jingzhaotoxin-V (JZTX-V) selectively inhibits A-type potassium channels. However, the specific effects of JZTX-V on the transient outward...

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Bibliographic Details
Main Authors: Yiya Zhang, Ji Luo, Juan He, Mingqiang Rong, Xiongzhi Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
JXTX-V
cardiomyocytes
action potential
Kv4.2 channel
hydrophobic patch
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00357/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00357/full

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