Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias

Summary: The Hereditary Spastic Paraplegias are a group of neurodegenerative diseases characterized by spasticity and weakness in the lower body. Owing to the combination of genetic diversity and variable clinical presentation, the Hereditary Spastic Paraplegias are a strong candidate for protein-pr...

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Bibliographic Details
Main Authors: Nikoleta Vavouraki, James E. Tomkins, Eleanna Kara, Henry Houlden, John Hardy, Marcus J. Tindall, Patrick A. Lewis, Claudia Manzoni
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:iScience
Subjects:
Bioinformatics
Biological sciences
Molecular network
Network
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221004521

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