Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation

Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation

We have shown that sphingosine 1-phosphate (S1P) generated by sphingosine kinase 2 (SK2) is toxic in neurons lacking S1P-lyase (SGPL1), the enzyme that catalyzes its irreversible cleavage. Interestingly, patients harboring mutations in the gene encoding this enzyme (<i>SGPL1</i>) often p...

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Bibliographic Details
Main Authors: Shah Alam, Antonia Piazzesi, Mariam Abd El Fatah, Maren Raucamp, Gerhild van Echten-Deckert
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
Sphingosine 1-phosphate (S1P), S1P-lyase (SGPL1), tau
calcium
histone acetylation
hippocampus
cortex
astrocytes
Online Access:https://www.mdpi.com/2073-4409/9/10/2189

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