Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

The distribution of complementary metabolic functions in hepatocytes along a portocentral axis is called liver zonation. Endothelial secreted Wnt ligands maintain metabolic zonation in the adult murine liver but whether those ligands are necessary to initiate zonation in the immature liver has been...

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Bibliographic Details
Main Authors: Ruihua Ma, Angelica S Martínez-Ramírez, Thomas L Borders, Fanding Gao, Beatriz Sosa-Pineda
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
hepatic zonation
Claudin-2
Wnt
hepatic sinusoids
carbon tetrachloride
Online Access:https://elifesciences.org/articles/46206

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