Spectratyping analysis of the islet-reactive T cell repertoire in diabetic NOD Igμ<sup>null </sup>mice after polyclonal B cell reconstitution

Spectratyping analysis of the islet-reactive T cell repertoire in diabetic NOD Igμ<sup>null </sup>mice after polyclonal B cell reconstitution

<p>Abstract</p> <p>Background</p> <p>Non Obese Diabetic mice lacking B cells (NOD.Igμ<sup>null </sup>mice) do not develop diabetes despite their susceptible background. Upon reconstitution of B cells using a chimera approach, animals start developing diabete...

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Bibliographic Details
Main Authors: Sercarz Eli E, Braciak Todd A, Sheng Huiming, Norori Patricia Y, Daneshjou Nazila, Vong Allen M, Gabaglia Claudia
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Journal of Translational Medicine
Subjects:
NOD
NOD.Igμ<sup>null</sup>
diabetes
immunoscope
T cell receptor
B cells
IL-6
Online Access:http://www.translational-medicine.com/content/9/1/101

Internet

http://www.translational-medicine.com/content/9/1/101

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