Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin

Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin

Abstract Background Iron overload, which is common in patients with haematological disorders, is known to have a suppressive effect on haematogenesis. However, the mechanism for this effect is still unclear. The antioxidant curcumin has been reported to protect against iron overload-induced bone mar...

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Bibliographic Details
Main Authors: Shujuan Zhou, Lan Sun, Shanhu Qian, Yongyong Ma, Ruye Ma, Yuqing Dong, Yifen Shi, Songfu Jiang, Haige Ye, Zhijian Shen, Shenghui Zhang, Jianping Shen, Kang Yu, Siqian Wang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
Curcumin
Iron overload
Bone marrow damage
Autophagy
Mitochondrial ROS
Online Access:https://doi.org/10.1186/s11658-020-00244-7

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