THE ALGORITHMS OF EXAMINATION OF PATIENTS WITH THYROID NODULES FORMATIONS: MODERN STATE OF THE QUESTION AND OUR OWN EXPERIENCE

• Main Authors: A. KH. Kade, E. I. Kleshchenko, B. B. Muselyan, N. P. Saatchiyan, A. I. Trofimenko, S. A. Zanin
• Format: Article
• Language: Russian
• Published: Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” 2016-10-01
• Series: Кубанский научный медицинский вестник
• Subjects: тэс-терапия; β-эндорфин; тироксин; гемитиреоидэктомия; послеоперационный гипотиреоз; крыса; tes-therapy; β-endorphin; thyroxine; hemithyroidectomy; postoperative hypothyroidism; rats
• Online Access: https://ksma.elpub.ru/jour/article/view/591
• ISSN: 1608-6228; 2541-9544

We conducted a research of the following ways of the post-operative hypothyroidism treatment: CES-therapy, hormone replacement therapy with L-thyroxine and combination therapy including two previously suggested approaches. The usage of CES-therapy in postoperative hypothyroidism leads to a significant decrease of TSH, fT3 and fT4. On this background, signs of protein-synthetic failure are observed. The isolated usage of L-thyroxin leads to a significant increase in the content of fT4 with a decrease of TSH and close to normal values of fT3 while there are signs of an expressed activation of protein catabolism. It is shown that only a comprehensive application of CES-therapy and L-thyroxine leads to the increase of TSH concentration amid rising fT3 and fT4. Herewith there is an observation of protein-synthetic failure symptoms.