The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus

The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus

Results of numerous studies give definitive evidence that phenofibrate affects activity of PPAR-a receptors in liver and thereby decreases the level oflipids responsible for the development of atherosclerosis (VLDL, small dense LDL); simultaneously, it increases the level of anti-atherogenic HDL.Act...

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Bibliographic Details
Main Authors: Larisa Viktorovna Koshel', Tatiana Ivanovna Romantsova
Format: Article
Language:English
Published: Endocrinology Research Centre 2009-12-01
Series:Сахарный диабет
Subjects:
phenofibrate
retinopathy
neuropathy
diabetes mellitus
Online Access:https://dia-endojournals.ru/dia/article/viewFile/5714/3492
Description
Summary:Results of numerous studies give definitive evidence that phenofibrate affects activity of PPAR-a receptors in liver and thereby decreases the level oflipids responsible for the development of atherosclerosis (VLDL, small dense LDL); simultaneously, it increases the level of anti-atherogenic HDL.Activation of PPAR-a receptors in vascular cells decreases activity of inflammation markers, such as C-reactive protein, TNF-a, IL-6, fibrinogen,etc. These effects of phenofibrate eventually lead to reduced risk of macro- and microvascular diabetic complications.
ISSN:2072-0351
2072-0378

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