Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats

Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats

The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg−1 b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activit...

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Main Authors: Vishnu Kumar, Mohammad Mubin Khan, Ashok Kumar Khanna, Ranjana Singh, Sushma Singh, Ramesh Chander, Farzana Mahdi, Abbas Ali Mahdi, Jitendra Kumar Saxena, Raj Kumar Singh
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1093/ecam/nen001
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spelling doaj-28b45fec7c194980977bd9321c08378a2020-11-25T00:53:05ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882010-01-017331732210.1093/ecam/nen001Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic RatsVishnu Kumar0Mohammad Mubin Khan1Ashok Kumar Khanna2Ranjana Singh3Sushma Singh4Ramesh Chander5Farzana Mahdi6Abbas Ali Mahdi7Jitendra Kumar Saxena8Raj Kumar Singh9Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow-226003, IndiaDivision of Biochemistry, Central Drug Research Institute, Lucknow-226001, IndiaDivision of Biochemistry, Central Drug Research Institute, Lucknow-226001, IndiaDepartment of Biochemistry, King George's Medical University, Lucknow-226003, IndiaDepartment of Biochemistry, King George's Medical University, Lucknow-226003, IndiaDepartment of Biochemistry, King George's Medical University, Lucknow-226003, IndiaDepartment of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow-226003, IndiaDepartment of Biochemistry, King George's Medical University, Lucknow-226003, IndiaDivision of Biochemistry, Central Drug Research Institute, Lucknow-226001, IndiaDepartment of Biochemistry, King George's Medical University, Lucknow-226003, IndiaThe lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg−1 b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.http://dx.doi.org/10.1093/ecam/nen001
collection DOAJ
language English
format Article
sources DOAJ
author Vishnu Kumar
Mohammad Mubin Khan
Ashok Kumar Khanna
Ranjana Singh
Sushma Singh
Ramesh Chander
Farzana Mahdi
Abbas Ali Mahdi
Jitendra Kumar Saxena
Raj Kumar Singh
spellingShingle Vishnu Kumar
Mohammad Mubin Khan
Ashok Kumar Khanna
Ranjana Singh
Sushma Singh
Ramesh Chander
Farzana Mahdi
Abbas Ali Mahdi
Jitendra Kumar Saxena
Raj Kumar Singh
Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats
Evidence-Based Complementary and Alternative Medicine
author_facet Vishnu Kumar
Mohammad Mubin Khan
Ashok Kumar Khanna
Ranjana Singh
Sushma Singh
Ramesh Chander
Farzana Mahdi
Abbas Ali Mahdi
Jitendra Kumar Saxena
Raj Kumar Singh
author_sort Vishnu Kumar
title Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats
title_short Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats
title_full Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats
title_fullStr Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats
title_full_unstemmed Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats
title_sort lipid lowering activity of anthocephalus indicus root in hyperlipidemic rats
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2010-01-01
description The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg−1 b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.
url http://dx.doi.org/10.1093/ecam/nen001
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