Effi ciency of allogenic platelet-rich plasmsa, combined with collagen, in rat's humerus injury healing

Effi ciency of allogenic platelet-rich plasmsa, combined with collagen, in rat's humerus injury healing

In experiment we studied influence of collagen, filled with platelet-rich plasma (PRP), on rats' bone regeneration in distal humerus. Used dose of PRP contained 130–135 pg/ml platelet-derived growth factor (PDGF). According to this level of PDGF, PRP-collagen treatment rapidly enhanced trabecul...

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Bibliographic Details
Main Authors: A. Yu. Vaza, M. S. Makarov, V. V. Slastinin, N. V. Borovkova, I. Yu. Klyukvin, D. Yu. Pokhitonov, I. N. Ponomarev
Format: Article
Language:English
Published: N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department 2016-06-01
Series:Transplantologiâ
Subjects:
platelet rich plasma
platelets with granules
pdgf
osteogenesis
Online Access:https://www.jtransplantologiya.ru/jour/article/view/121
Description
Summary:In experiment we studied influence of collagen, filled with platelet-rich plasma (PRP), on rats' bone regeneration in distal humerus. Used dose of PRP contained 130–135 pg/ml platelet-derived growth factor (PDGF). According to this level of PDGF, PRP-collagen treatment rapidly enhanced trabecular bones' growth, stimu-lated angiogenesis and reduced intensity of inflammation. Allogenic PRP, addressed to all experimental animals, allowed to make humerus healing 2 times shorter.
ISSN:2074-0506
2542-0909

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