Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice

Spatial learning and memory deficits associated with hippocampal synaptic plasticity impairments are commonly observed during aging. Besides, the beneficial role of dietary polyphenols has been suggested as potential functional food candidates to prevent this memory decline. Indeed, polyphenols coul...

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Main Authors: Julien eBensalem, Laure eServant, Serge eAlfos, David eGaudout, Sophie eLaye, Véronique ePallet, Pauline eLafenetre
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00009/full
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spelling doaj-289fd5d8a0844bb59ba254256e431a9d2020-11-24T22:45:35ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532016-02-011010.3389/fnbeh.2016.00009147313Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged miceJulien eBensalem0Julien eBensalem1Julien eBensalem2Laure eServant3Laure eServant4Serge eAlfos5Serge eAlfos6Serge eAlfos7David eGaudout8Sophie eLaye9Sophie eLaye10Véronique ePallet11Véronique ePallet12Véronique ePallet13Pauline eLafenetre14Pauline eLafenetre15Pauline eLafenetre16Univ. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxActiv'InsideUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxBordeaux INP, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxActiv'InsideUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxBordeaux INP, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxBordeaux INP, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxSpatial learning and memory deficits associated with hippocampal synaptic plasticity impairments are commonly observed during aging. Besides, the beneficial role of dietary polyphenols has been suggested as potential functional food candidates to prevent this memory decline. Indeed, polyphenols could potentiate the signaling pathways of synaptic plasticity underlying learning and memory. In this study, spatial learning deficits of middle-aged mice were first highlighted and characterized according to navigation patterns in the Morris water maze task. An eight-week polyphenol-enriched diet, containing a polyphenol-rich extract from grape and blueberry (PEGB) (from the Neurophenols Consortium) with high contents of flavonoids, stilbenes and phenolic acids, was then successful in reversing these age-induced effects. The use of spatial strategies was indeed delayed with aging whereas a polyphenol supplementation could promote the occurrence of spatial strategies. These behavioral results were associated with neurobiological changes: while the expression of hippocampal CaMKII mRNA levels was reduced in middle-aged animals, the polyphenol-enriched diet could rescue them. Besides, an increased expression of NGF mRNA levels was also observed in supplemented adult and middle-aged mice. Thus these data suggest that supplementation with polyphenols could be an efficient nutritional way to prevent age-induced cognitive decline.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00009/fullAgingHippocampusPolyphenolsstrategyBerriesLearning and Memory (Neurosciences)
collection DOAJ
language English
format Article
sources DOAJ
author Julien eBensalem
Julien eBensalem
Julien eBensalem
Laure eServant
Laure eServant
Serge eAlfos
Serge eAlfos
Serge eAlfos
David eGaudout
Sophie eLaye
Sophie eLaye
Véronique ePallet
Véronique ePallet
Véronique ePallet
Pauline eLafenetre
Pauline eLafenetre
Pauline eLafenetre
spellingShingle Julien eBensalem
Julien eBensalem
Julien eBensalem
Laure eServant
Laure eServant
Serge eAlfos
Serge eAlfos
Serge eAlfos
David eGaudout
Sophie eLaye
Sophie eLaye
Véronique ePallet
Véronique ePallet
Véronique ePallet
Pauline eLafenetre
Pauline eLafenetre
Pauline eLafenetre
Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice
Frontiers in Behavioral Neuroscience
Aging
Hippocampus
Polyphenols
strategy
Berries
Learning and Memory (Neurosciences)
author_facet Julien eBensalem
Julien eBensalem
Julien eBensalem
Laure eServant
Laure eServant
Serge eAlfos
Serge eAlfos
Serge eAlfos
David eGaudout
Sophie eLaye
Sophie eLaye
Véronique ePallet
Véronique ePallet
Véronique ePallet
Pauline eLafenetre
Pauline eLafenetre
Pauline eLafenetre
author_sort Julien eBensalem
title Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice
title_short Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice
title_full Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice
title_fullStr Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice
title_full_unstemmed Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice
title_sort dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice
publisher Frontiers Media S.A.
series Frontiers in Behavioral Neuroscience
issn 1662-5153
publishDate 2016-02-01
description Spatial learning and memory deficits associated with hippocampal synaptic plasticity impairments are commonly observed during aging. Besides, the beneficial role of dietary polyphenols has been suggested as potential functional food candidates to prevent this memory decline. Indeed, polyphenols could potentiate the signaling pathways of synaptic plasticity underlying learning and memory. In this study, spatial learning deficits of middle-aged mice were first highlighted and characterized according to navigation patterns in the Morris water maze task. An eight-week polyphenol-enriched diet, containing a polyphenol-rich extract from grape and blueberry (PEGB) (from the Neurophenols Consortium) with high contents of flavonoids, stilbenes and phenolic acids, was then successful in reversing these age-induced effects. The use of spatial strategies was indeed delayed with aging whereas a polyphenol supplementation could promote the occurrence of spatial strategies. These behavioral results were associated with neurobiological changes: while the expression of hippocampal CaMKII mRNA levels was reduced in middle-aged animals, the polyphenol-enriched diet could rescue them. Besides, an increased expression of NGF mRNA levels was also observed in supplemented adult and middle-aged mice. Thus these data suggest that supplementation with polyphenols could be an efficient nutritional way to prevent age-induced cognitive decline.
topic Aging
Hippocampus
Polyphenols
strategy
Berries
Learning and Memory (Neurosciences)
url http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00009/full
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