Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice
Spatial learning and memory deficits associated with hippocampal synaptic plasticity impairments are commonly observed during aging. Besides, the beneficial role of dietary polyphenols has been suggested as potential functional food candidates to prevent this memory decline. Indeed, polyphenols coul...
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doaj-289fd5d8a0844bb59ba254256e431a9d2020-11-24T22:45:35ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532016-02-011010.3389/fnbeh.2016.00009147313Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged miceJulien eBensalem0Julien eBensalem1Julien eBensalem2Laure eServant3Laure eServant4Serge eAlfos5Serge eAlfos6Serge eAlfos7David eGaudout8Sophie eLaye9Sophie eLaye10Véronique ePallet11Véronique ePallet12Véronique ePallet13Pauline eLafenetre14Pauline eLafenetre15Pauline eLafenetre16Univ. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxActiv'InsideUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxBordeaux INP, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxActiv'InsideUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxBordeaux INP, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxUniv. Bordeaux, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxINRA, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxBordeaux INP, Nutrition et neurobiologie intégrée, UMR1286, F-33076, BordeauxSpatial learning and memory deficits associated with hippocampal synaptic plasticity impairments are commonly observed during aging. Besides, the beneficial role of dietary polyphenols has been suggested as potential functional food candidates to prevent this memory decline. Indeed, polyphenols could potentiate the signaling pathways of synaptic plasticity underlying learning and memory. In this study, spatial learning deficits of middle-aged mice were first highlighted and characterized according to navigation patterns in the Morris water maze task. An eight-week polyphenol-enriched diet, containing a polyphenol-rich extract from grape and blueberry (PEGB) (from the Neurophenols Consortium) with high contents of flavonoids, stilbenes and phenolic acids, was then successful in reversing these age-induced effects. The use of spatial strategies was indeed delayed with aging whereas a polyphenol supplementation could promote the occurrence of spatial strategies. These behavioral results were associated with neurobiological changes: while the expression of hippocampal CaMKII mRNA levels was reduced in middle-aged animals, the polyphenol-enriched diet could rescue them. Besides, an increased expression of NGF mRNA levels was also observed in supplemented adult and middle-aged mice. Thus these data suggest that supplementation with polyphenols could be an efficient nutritional way to prevent age-induced cognitive decline.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00009/fullAgingHippocampusPolyphenolsstrategyBerriesLearning and Memory (Neurosciences) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julien eBensalem Julien eBensalem Julien eBensalem Laure eServant Laure eServant Serge eAlfos Serge eAlfos Serge eAlfos David eGaudout Sophie eLaye Sophie eLaye Véronique ePallet Véronique ePallet Véronique ePallet Pauline eLafenetre Pauline eLafenetre Pauline eLafenetre |
spellingShingle |
Julien eBensalem Julien eBensalem Julien eBensalem Laure eServant Laure eServant Serge eAlfos Serge eAlfos Serge eAlfos David eGaudout Sophie eLaye Sophie eLaye Véronique ePallet Véronique ePallet Véronique ePallet Pauline eLafenetre Pauline eLafenetre Pauline eLafenetre Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice Frontiers in Behavioral Neuroscience Aging Hippocampus Polyphenols strategy Berries Learning and Memory (Neurosciences) |
author_facet |
Julien eBensalem Julien eBensalem Julien eBensalem Laure eServant Laure eServant Serge eAlfos Serge eAlfos Serge eAlfos David eGaudout Sophie eLaye Sophie eLaye Véronique ePallet Véronique ePallet Véronique ePallet Pauline eLafenetre Pauline eLafenetre Pauline eLafenetre |
author_sort |
Julien eBensalem |
title |
Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice |
title_short |
Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice |
title_full |
Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice |
title_fullStr |
Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice |
title_full_unstemmed |
Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice |
title_sort |
dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2016-02-01 |
description |
Spatial learning and memory deficits associated with hippocampal synaptic plasticity impairments are commonly observed during aging. Besides, the beneficial role of dietary polyphenols has been suggested as potential functional food candidates to prevent this memory decline. Indeed, polyphenols could potentiate the signaling pathways of synaptic plasticity underlying learning and memory. In this study, spatial learning deficits of middle-aged mice were first highlighted and characterized according to navigation patterns in the Morris water maze task. An eight-week polyphenol-enriched diet, containing a polyphenol-rich extract from grape and blueberry (PEGB) (from the Neurophenols Consortium) with high contents of flavonoids, stilbenes and phenolic acids, was then successful in reversing these age-induced effects. The use of spatial strategies was indeed delayed with aging whereas a polyphenol supplementation could promote the occurrence of spatial strategies. These behavioral results were associated with neurobiological changes: while the expression of hippocampal CaMKII mRNA levels was reduced in middle-aged animals, the polyphenol-enriched diet could rescue them. Besides, an increased expression of NGF mRNA levels was also observed in supplemented adult and middle-aged mice. Thus these data suggest that supplementation with polyphenols could be an efficient nutritional way to prevent age-induced cognitive decline. |
topic |
Aging Hippocampus Polyphenols strategy Berries Learning and Memory (Neurosciences) |
url |
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00009/full |
work_keys_str_mv |
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