Quantitative genome-wide genetic interaction screens reveal global epistatic relationships of protein complexes in Escherichia coli.

Quantitative genome-wide genetic interaction screens reveal global epistatic relationships of protein complexes in Escherichia coli.

Large-scale proteomic analyses in Escherichia coli have documented the composition and physical relationships of multiprotein complexes, but not their functional organization into biological pathways and processes. Conversely, genetic interaction (GI) screens can provide insights into the biological...

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Main Authors: Mohan Babu, Roland Arnold, Cedoljub Bundalovic-Torma, Alla Gagarinova, Keith S Wong, Ashwani Kumar, Geordie Stewart, Bahram Samanfar, Hiroyuki Aoki, Omar Wagih, James Vlasblom, Sadhna Phanse, Krunal Lad, Angela Yeou Hsiung Yu, Christopher Graham, Ke Jin, Eric Brown, Ashkan Golshani, Philip Kim, Gabriel Moreno-Hagelsieb, Jack Greenblatt, Walid A Houry, John Parkinson, Andrew Emili
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3930520?pdf=render

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