Machine learning model for sequence-driven DNA G-quadruplex formation

Abstract We describe a sequence-based computational model to predict DNA G-quadruplex (G4) formation. The model was developed using large-scale machine learning from an extensive experimental G4-formation dataset, recently obtained for the human genome via G4-seq methodology. Our model differentiate...

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Bibliographic Details
Main Authors: Aleksandr B. Sahakyan, Vicki S. Chambers, Giovanni Marsico, Tobias Santner, Marco Di Antonio, Shankar Balasubramanian
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-14017-4

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