FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

In cancer cells, telomeres can be elongated through homology directed-repair pathways in a process known as Alternative Lengthening of Telomeres (ALT). Here, the authors reveal that FANCM regulates ALT activity and ALT cell proliferation by limiting the activity of uncontrolled BLM and telomeric R-l...

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Bibliographic Details
Main Authors: Bruno Silva, Richard Pentz, Ana Margarida Figueira, Rajika Arora, Yong Woo Lee, Charlotte Hodson, Harry Wischnewski, Andrew J. Deans, Claus M. Azzalin
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10179-z

Internet

https://doi.org/10.1038/s41467-019-10179-z

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