Isoalantolactone inhibits IKKβ kinase activity to interrupt the NF‐κB/COX‐2‐mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma

Isoalantolactone inhibits IKKβ kinase activity to interrupt the NF‐κB/COX‐2‐mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma

Abstract Isoalantolactone (IATL), a sesquiterpene lactone compound, possesses many pharmacological and biological activities, but its role in glioblastoma (GBM) treatment is still unknown. The aim of the current study was to investigate the antiglioma effects of IATL and to explore the underlying mo...

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Bibliographic Details
Main Authors: Jin‐Shan Xing, Xun Wang, Yu‐Long Lan, Jia‐Cheng Lou, Binbin Ma, Tingzhun Zhu, Hongqiang Zhang, Dongsheng Wang, Zhikuan Yu, Zhongbo Yuan, Xin‐Yu Li, Bo Zhang
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Cancer Medicine
Subjects:
cofilin
COX‐2
glioblastoma
IATL
NF‐κB
Online Access:https://doi.org/10.1002/cam4.2013

Internet

https://doi.org/10.1002/cam4.2013

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