Immunity to Respiratory Infection Is Reinforced Through Early Proliferation of Lymphoid TRM Cells and Prompt Arrival of Effector CD8 T Cells in the Lungs

Immunity to Respiratory Infection Is Reinforced Through Early Proliferation of Lymphoid TRM Cells and Prompt Arrival of Effector CD8 T Cells in the Lungs

Cross-protection between serologically distinct strains of influenza A virus (IAV) is mediated by memory CD8 T cells that recognize epitopes from conserved viral proteins. Early viral control begins with activation of tissue-resident memory CD8 T cells (TRM) cells at the site of viral replication. T...

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Bibliographic Details
Main Authors: Jenny E. Suarez-Ramirez, Karthik Chandiran, Stefan Brocke, Linda S. Cauley
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
immune regulation
respiratory infection
cytotoxic T cell
viral immunity
immunological “memory”
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01370/full

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