Clinical, radiological and molecular characterization of intramedullary astrocytomas

Clinical, radiological and molecular characterization of intramedullary astrocytomas

Abstract Intramedullary astrocytomas (IMAs) are rare tumors, and few studies specific to the molecular alterations of IMAs have been performed. Recently, KIAA1549-BRAF fusions and the H3F3A p.K27M mutation have been described in low-grade (LG) and high-grade (HG) IMAs, respectively. In the present s...

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Bibliographic Details
Main Authors: Laetitia Lebrun, Barbara Meléndez, Oriane Blanchard, Nancy De Nève, Claude Van Campenhout, Julie Lelotte, Danielle Balériaux, Matteo Riva, Jacques Brotchi, Michaël Bruneau, Olivier De Witte, Christine Decaestecker, Nicky D’Haene, Isabelle Salmon
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Acta Neuropathologica Communications
Subjects:
Intramedullary astrocytomas-glial tumor-spinal cord-targeted next-generation sequencing-H3F3A K27M-KIAA1549-BRAF
Online Access:http://link.springer.com/article/10.1186/s40478-020-00962-1

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