Selective deficiency in endothelial PTP1B protects from diabetes and endoplasmic reticulum stress-associated endothelial dysfunction via preventing endothelial cell apoptosis

Selective deficiency in endothelial PTP1B protects from diabetes and endoplasmic reticulum stress-associated endothelial dysfunction via preventing endothelial cell apoptosis

Diabetes notably increases the risk for endothelial dysfunction, a main precursor for microvascular complications. While endoplasmic reticulum stress (ERS) and protein tyrosine phosphatase 1B (PTP1B) have been associated with endothelial dysfunction in resistance vessels, whether these mechanisms al...

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Bibliographic Details
Main Authors: Samuel Legeay, Pierre Fautrat, J. Blake Norman, Galina Antonova, Simone Kennard, Thiago Bruder-Nascimento, Vijay S. Patel, Sebastien Faure, Eric J. Belin de Chantemèle
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Endothelial function
Diabetes
Protein tyrosine phosphatase 1B
Endoplasmic reticulum stress
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303929

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