Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1

Summary: Neural network remodeling underpins the ability to remember life experiences, but little is known about the long-term plasticity of neural populations. To study how the brain encodes episodic events, we used time-lapse two-photon microscopy and a fluorescent reporter of neural plasticity ba...

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Main Authors:	Alessio Attardo, Ju Lu, Takashi Kawashima, Hiroyuki Okuno, James E. Fitzgerald, Haruhiko Bito, Mark J. Schnitzer
Format:	Article
Language:	English
Published:	Elsevier 2018-10-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124718315249

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spelling	doaj-2874f78060bb49c79f217ede6deab5b62020-11-25T01:31:30ZengElsevierCell Reports2211-12472018-10-01253640650.e2Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1Alessio Attardo0Ju Lu1Takashi Kawashima2Hiroyuki Okuno3James E. Fitzgerald4Haruhiko Bito5Mark J. Schnitzer6James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany; Corresponding authorJames H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA 94305, USADepartment of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, JapanJames H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA 94305, USADepartment of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; CREST-AMED, Chiyoda-ku, Tokyo 100-0004, JapanJames H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Corresponding authorSummary: Neural network remodeling underpins the ability to remember life experiences, but little is known about the long-term plasticity of neural populations. To study how the brain encodes episodic events, we used time-lapse two-photon microscopy and a fluorescent reporter of neural plasticity based on an enhanced form of the synaptic activity-responsive element (E-SARE) within the Arc promoter to track thousands of CA1 hippocampal pyramidal cells over weeks in mice that repeatedly encountered different environments. Each environment evokes characteristic patterns of ensemble neural plasticity, but with each encounter, the set of activated cells gradually evolves. After repeated exposures, the plasticity patterns evoked by an individual environment progressively stabilize. Compared with young adults, plasticity patterns in aged mice are less specific to individual environments and less stable across repeat experiences. Long-term consolidation of hippocampal plasticity patterns may support long-term memory formation, whereas weaker consolidation in aged subjects might reflect declining memory function. : Attardo et al. use a fluorescent reporter of neural plasticity to image ensemble plasticity patterns in hippocampal neurons of live mice. These patterns turn over but progressively stabilize across repeated explorations of an enriched environment. In aged mice, plasticity patterns do not stabilize and are less specific to individual environments. Keywords: hippocampus, plasticity, immediate-early genes, two-photon imaging, representations, aginghttp://www.sciencedirect.com/science/article/pii/S2211124718315249
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alessio Attardo Ju Lu Takashi Kawashima Hiroyuki Okuno James E. Fitzgerald Haruhiko Bito Mark J. Schnitzer
spellingShingle	Alessio Attardo Ju Lu Takashi Kawashima Hiroyuki Okuno James E. Fitzgerald Haruhiko Bito Mark J. Schnitzer Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1 Cell Reports
author_facet	Alessio Attardo Ju Lu Takashi Kawashima Hiroyuki Okuno James E. Fitzgerald Haruhiko Bito Mark J. Schnitzer
author_sort	Alessio Attardo
title	Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1
title_short	Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1
title_full	Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1
title_fullStr	Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1
title_full_unstemmed	Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1
title_sort	long-term consolidation of ensemble neural plasticity patterns in hippocampal area ca1
publisher	Elsevier
series	Cell Reports
issn	2211-1247
publishDate	2018-10-01
description	Summary: Neural network remodeling underpins the ability to remember life experiences, but little is known about the long-term plasticity of neural populations. To study how the brain encodes episodic events, we used time-lapse two-photon microscopy and a fluorescent reporter of neural plasticity based on an enhanced form of the synaptic activity-responsive element (E-SARE) within the Arc promoter to track thousands of CA1 hippocampal pyramidal cells over weeks in mice that repeatedly encountered different environments. Each environment evokes characteristic patterns of ensemble neural plasticity, but with each encounter, the set of activated cells gradually evolves. After repeated exposures, the plasticity patterns evoked by an individual environment progressively stabilize. Compared with young adults, plasticity patterns in aged mice are less specific to individual environments and less stable across repeat experiences. Long-term consolidation of hippocampal plasticity patterns may support long-term memory formation, whereas weaker consolidation in aged subjects might reflect declining memory function. : Attardo et al. use a fluorescent reporter of neural plasticity to image ensemble plasticity patterns in hippocampal neurons of live mice. These patterns turn over but progressively stabilize across repeated explorations of an enriched environment. In aged mice, plasticity patterns do not stabilize and are less specific to individual environments. Keywords: hippocampus, plasticity, immediate-early genes, two-photon imaging, representations, aging
url	http://www.sciencedirect.com/science/article/pii/S2211124718315249
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Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1

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