Staphylococcus aureus Phenol-Soluble Modulins α1–α3 Act as Novel Toll-Like Receptor (TLR) 4 Antagonists to Inhibit HMGB1/TLR4/NF-κB Signaling Pathway

Staphylococcus aureus Phenol-Soluble Modulins α1–α3 Act as Novel Toll-Like Receptor (TLR) 4 Antagonists to Inhibit HMGB1/TLR4/NF-κB Signaling Pathway

Phenol-soluble modulins (PSMs) have recently emerged as key virulence determinants, particularly in highly aggressive Staphylococcus aureus isolates. These peptides contribute to the pathogenesis of S. aureus infections, participating in multiple inflammatory responses. Here, we report a new role fo...

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Bibliographic Details
Main Authors: Ming Chu, Mingya Zhou, Caihong Jiang, Xi Chen, Likai Guo, Mingbo Zhang, Zhengyun Chu, Yuedan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
Staphylococcus aureus
phenol-soluble modulins
HMGB1
toll-like receptor 4
NF-κB
antagonists
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00862/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00862/full

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