Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses.
Although an impact of processing on immunogenicity of food proteins has clearly been demonstrated, the underlying mechanisms are still unclear. We applied 3 different processing methods: wet heating (60 °C) and low- or high-temperature (50 °C or 130 °C, respectively) dry-heating in absence or presen...
Main Authors: | Ying Deng, Coen Govers, Malgorzata Teodorowicz, Ieva Liobyte, Ilaria De Simone, Kasper Hettinga, Harry J Wichers |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0236212 |
Similar Items
-
A THP-1 Cell Line-Based Exploration of Immune Responses Toward Heat-Treated BLG
by: Ying Deng, et al.
Published: (2021-01-01) -
No Glycation Required: Interference of Casein in AGE Receptor Binding Tests
by: Hannah E. Zenker, et al.
Published: (2021-08-01) -
Macrophages treated with non-digestible polysaccharides reveal a transcriptionally unique phenotype
by: Yongfu Tang, et al.
Published: (2017-09-01) -
Binding of CML-Modified as Well as Heat-Glycated β-lactoglobulin to Receptors for AGEs is Determined by Charge and Hydrophobicity
by: Hannah E. Zenker, et al.
Published: (2020-06-01) -
Suppression of endothelial or lipoprotein lipase in THP-1 macrophages attenuates proinflammatory cytokine secretions⃞
by: Guosong Qiu, et al.
Published: (2007-02-01)