An EM algorithm to improve the estimation of the probability of clonal relatedness of pairs of tumors in cancer patients

An EM algorithm to improve the estimation of the probability of clonal relatedness of pairs of tumors in cancer patients

Abstract Background We previously introduced a random-effects model to analyze a set of patients, each of which has two distinct tumors. The goal is to estimate the proportion of patients for which one of the tumors is a metastasis of the other, i.e. where the tumors are clonally related. Matches of...

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Bibliographic Details
Main Authors: Audrey Mauguen, Venkatraman E. Seshan, Irina Ostrovnaya, Colin B. Begg
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Bioinformatics
Subjects:
Cancer
Clonality
EM algorithm
Tumor mutation
Parameter estimation
Random effect model
Online Access:http://link.springer.com/article/10.1186/s12859-019-3148-z

Internet

http://link.springer.com/article/10.1186/s12859-019-3148-z

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