Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity

Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity

Abstract Background Type III polyketide synthases (PKSs) are simple homodimer ketosynthases that distribute across plants, fungi, and bacteria, catalyzing formation of pyrone- and resorcinol-types aromatic polyketides with various bioactivities. The broad substrate promiscuity displayed by type III...

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Bibliographic Details
Main Authors: Lukuan Hou, Huiming Huang, Huayue Li, Shuyao Wang, Jianhua Ju, Wenli Li
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Microbial Cell Factories
Subjects:
Violapyrones (VLPs)
Overexpression
Type III polyketide synthase (PKS)
Anti-influenza A (H1N1) virus activity
Online Access:http://link.springer.com/article/10.1186/s12934-018-0908-9

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