Effects of Qingfei Xiaoyan pill combined with ceftriaxone and azithromycin on immune index, oxidative stress and inflammatory index in senile CAP patients

• Main Authors: Xiao-Rui Bai, Le Gao, Li Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-05-01
• Series: Journal of Hainan Medical University
• Subjects: qingfei xiaoyan pill; cap; immunity; oxidative stress; inflammation
• Online Access: http://www.hnykdxxb.com/PDF/201910/9.pdf

Objective: To explore the effects of Qingfei Xiaoyan pill combined with ceftriaxone and azithromycin on immune index, oxidative stress and inflammatory index in senile CAP patients. Methods: A total of 130 patients with CAP admitted to Yulin first hospital from October 2016 to December 2017 were randomly divided into control group (n = 65) and observation group (n = 65), the control group was treated with ceftriaxone combined with azithromycin, while the observation group was treated with Qingfei Xiaoyan Pill on the basis of the control group, the changes of cellular humoral immune function, oxidative stress index and inflammatory factors were compared between the two groups before and after treatment. Results: After treatment, the levels of CD4+ and CD4+/CD8+ in both groups were significantly higher than before treatment, while the level of CD8+ was significantly lower than before treatment, the levels of CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group, while the level of CD8+ was significantly lower than those in the control group; the levels of IgA and IgM in the observation group were significantly higher than those in the control group; the levels of MDA and SOD in the observation group were significantly lower than those in the control group, and the level of MDA in the observation group was significantly lower than that in the control group, the levels of SOD in the observation group were significantly higher than those in the control group; the levels of PCT and CRP in the two groups were significantly lower than those before treatment , and the levels of PCT and CRP in the observation group were significantly lower than those in the control group. Conclusions: Qingfei Xiaoyan pill combined with ceftriaxone and azithromycin can effectively enhance the immune function of elderly patients with CAP, enhance the body's antioxidant effect and reduce its inflammatory reaction, which is of clinical significance.