EVIDENCE FOR A 12 kDa "CARRIER PROTEIN" FOR NATRIURETIC HORMONE
The search for the elusive natriuretic hormone continues. In this review evidence is presented that isolating the carrier protein for natriuretic hormone is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12 kDa while the final hormone has...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00196/full |
| Summary: | The search for the elusive natriuretic hormone continues. In this review evidence is presented that isolating the carrier protein for natriuretic hormone is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12 kDa while the final hormone has a molecular weight of 408 daltons. Both compounds inhibit Na-K-ATPase but the compound containing the carrier protein predominates. The question has been raised as to whether the carrier protein is in actuality proANF, a 17 kDa protein that can be split between a 14 kDa protein (the presumptive proANF) and the 3 kDa ANF. |
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| ISSN: | 1664-2392 |