HEART-TYPE FATTY ACID BINDING PROTEIN-BASED ExPRESS TEST IN THE DIAGNOSTICS OF ACUTE MYOCARDIAL INFARCTION

• Main Authors: V. V. Ryabov, M. A. Kirgizova, V. A. Markov
• Format: Article
• Language: Russian
• Published: «FIRMA «SILICEA» LLC 2014-02-01
• Series: Российский кардиологический журнал
• Subjects: fatty acid binding protein; acute myocardial infarction; troponin i
• Online Access: https://russjcardiol.elpub.ru/jour/article/view/12

Aim. To compare the effectiveness of two express tests — CardioFABP andTroponin I WB-Check-1 in the diagnostics of acute myocardial infarction (AMI).Material and methods. The study included 38 patients who were hospitalised with the acute coronary syndrome (ACS) diagnosis within the first 12 hours after the painonset. At the admission, the peripheral blood levels of CK-MB and troponin I werequalitatively assessed using the immunochemiluminescent analyser “Access-2”(Beckman Coulter, USA). In addition, the express test Troponin I WB-Check-1(VEDALAB, France; sensitivity 1 ng/ml) was used. Qualitative assessment of hearttypefatty acid binding protein (hFABP) was performed with the express test“CardioFABP” (Biotest, Russia; sensitivity 15 ng/ml). For all tests, diagnosticsensitivity, diagnostic specificity, positive and negative predictive value, anddiagnostic effectiveness were assessed.Results. The express tests for hFABP and troponin I demonstrated high positivepredictive value and diagnostic specificity (100%). However, both tests also had falsenegative results, and, therefore, negative predictive value was low for both the hFABPtest (23,5%) and the troponin I test (17,4%). Diagnostic sensitivity was 35,4% for the troponin I express test and 57,6% for the hFABP express test. Diagnostic effectiveness was higher for the hFABP express test (62,2%). All positive results of the hFABPexpress test were confirmed by the other tests, which resulted in high positive predictive value (100%) and high diagnostic specificity (100%). In patients within the first 6 hours of ACS, diagnostic sensitivity of the hFABP express test was significantlyhigher than in those with a longer ACS duration (83,3% vs. 42,8%, respectively).Conclusion. The higher diagnostic sensitivity and diagnostic effectiveness of thehFABP-based express test in the first 6 hours of ACS, compared to a qualitativeassessment of troponin I and a later assessment of hFABP, agrees with the earlierobtained data and confirms the status of hFABP as the earliest marker of myocardialnecrosis.