ETosis: A Microbicidal Mechanism beyond Cell Death

ETosis: A Microbicidal Mechanism beyond Cell Death

Netosis is a recently described type of neutrophil death occurring with the release to the extracellular milieu of a lattice composed of DNA associated with histones and granular and cytoplasmic proteins. These webs, initially named neutrophil extracellular traps (NETs), ensnare and kill microorgani...

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Main Authors: Anderson B. Guimarães-Costa, Michelle T. C. Nascimento, Amanda B. Wardini, Lucia H. Pinto-da-Silva, Elvira M. Saraiva
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Parasitology Research
Online Access:http://dx.doi.org/10.1155/2012/929743
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spelling doaj-283e3520702c49f49428bde78e3402da2020-11-24T20:53:04ZengHindawi LimitedJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/929743929743ETosis: A Microbicidal Mechanism beyond Cell DeathAnderson B. Guimarães-Costa0Michelle T. C. Nascimento1Amanda B. Wardini2Lucia H. Pinto-da-Silva3Elvira M. Saraiva4Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), 21941-901 Rio de Janeiro, RJ, BrazilInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), 21941-901 Rio de Janeiro, RJ, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), 21941-901 Rio de Janeiro, RJ, BrazilInstituto de Veterinária, Universidade Federal Rural do Rio de Janeiro (UFRRJ), 23890-000 Seropedica, RJ, BrazilInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), 21941-901 Rio de Janeiro, RJ, BrazilNetosis is a recently described type of neutrophil death occurring with the release to the extracellular milieu of a lattice composed of DNA associated with histones and granular and cytoplasmic proteins. These webs, initially named neutrophil extracellular traps (NETs), ensnare and kill microorganisms. Similarly, other cell types, such as eosinophils, mast cells, and macrophages, can also dye by this mechanism; thus, it was renamed as ETosis, meaning death with release of extracellular traps (ETs). Here, we review the mechanism of NETosis/etosis, emphasizing its role in diseases caused by protozoan parasites, fungi, and viruses.http://dx.doi.org/10.1155/2012/929743
collection DOAJ
language English
format Article
sources DOAJ
author Anderson B. Guimarães-Costa
Michelle T. C. Nascimento
Amanda B. Wardini
Lucia H. Pinto-da-Silva
Elvira M. Saraiva
spellingShingle Anderson B. Guimarães-Costa
Michelle T. C. Nascimento
Amanda B. Wardini
Lucia H. Pinto-da-Silva
Elvira M. Saraiva
ETosis: A Microbicidal Mechanism beyond Cell Death
Journal of Parasitology Research
author_facet Anderson B. Guimarães-Costa
Michelle T. C. Nascimento
Amanda B. Wardini
Lucia H. Pinto-da-Silva
Elvira M. Saraiva
author_sort Anderson B. Guimarães-Costa
title ETosis: A Microbicidal Mechanism beyond Cell Death
title_short ETosis: A Microbicidal Mechanism beyond Cell Death
title_full ETosis: A Microbicidal Mechanism beyond Cell Death
title_fullStr ETosis: A Microbicidal Mechanism beyond Cell Death
title_full_unstemmed ETosis: A Microbicidal Mechanism beyond Cell Death
title_sort etosis: a microbicidal mechanism beyond cell death
publisher Hindawi Limited
series Journal of Parasitology Research
issn 2090-0023
2090-0031
publishDate 2012-01-01
description Netosis is a recently described type of neutrophil death occurring with the release to the extracellular milieu of a lattice composed of DNA associated with histones and granular and cytoplasmic proteins. These webs, initially named neutrophil extracellular traps (NETs), ensnare and kill microorganisms. Similarly, other cell types, such as eosinophils, mast cells, and macrophages, can also dye by this mechanism; thus, it was renamed as ETosis, meaning death with release of extracellular traps (ETs). Here, we review the mechanism of NETosis/etosis, emphasizing its role in diseases caused by protozoan parasites, fungi, and viruses.
url http://dx.doi.org/10.1155/2012/929743
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AT elviramsaraiva etosisamicrobicidalmechanismbeyondcelldeath
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