Diphtheria Antibodies and T lymphocyte Counts in Patients Infected with HIV-1

Diphtheria Antibodies and T lymphocyte Counts in Patients Infected with HIV-1

We assessed the IgG levels anti-diphtheria (D-Ab) and T cell counts (CD4+ and CD8+) in HIV-1 infected subjects undergoing or not highly active antiretroviral therapy (HAART). Approximately 70% of all HIV-1 patients were unprotected against diphtheria. There were no differences in D-Ab according to C...

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Bibliographic Details
Main Authors: Francisco A. B. Speranza, Solange K. Ishii, Luiz C. S. Thuler, Paulo V. Damasco, Raphael Hirata Jr, Ana L. Mattos-Guaraldi, Lucimar G. Milagres
Format: Article
Language:English
Published: Sociedade Brasileira de Microbiologia 2012-09-01
Series:Brazilian Journal of Microbiology
Subjects:
HIV-1
antibody to diphtheria toxin
vaccination
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000300014
Description
Summary:We assessed the IgG levels anti-diphtheria (D-Ab) and T cell counts (CD4+ and CD8+) in HIV-1 infected subjects undergoing or not highly active antiretroviral therapy (HAART). Approximately 70% of all HIV-1 patients were unprotected against diphtheria. There were no differences in D-Ab according to CD4 counts. Untreated patients had higher D-Ab (geometric mean of 0.62 IU/ml) than HAART-patients (geometric mean of 0.39 IU/ml). The data indicated the necessity of keeping all HIV-1 patients up-to-date with their vaccination.
ISSN:1517-8382
1678-4405

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