Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators

Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators

Aging modifies not only multiple cellular and homeostatic systems, but also biological rhythms. The circadian system is driven by a central hypothalamic oscillator which entrains peripheral oscillators, in both cases underlain by circadian genes. Our aim was to characterize the effect of aging in th...

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Bibliographic Details
Main Authors: Cristina Camello-Almaraz, Francisco E. Martin-Cano, Francisco J. Santos, Mª Teresa Espin, Juan Antonio Madrid, Maria J. Pozo, Pedro J. Camello
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
circadian rhythms
colon
smooth muscle
clock genes
contractility
calcium signals
Online Access:https://www.mdpi.com/1422-0067/21/2/674

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