Inhibitory Effect of Flavonoids on the Efflux of 𝑁-Acetyl 5-Aminosalicylic Acid Intracellularly Formed in Caco-2 Cells

Inhibitory Effect of Flavonoids on the Efflux of 𝑁-Acetyl 5-Aminosalicylic Acid Intracellularly Formed in Caco-2 Cells

𝑁-acetyl 5-aminosalicylic acid (5-AcASA) that was intracellularly formed from 5-aminosalicylic acid (5-ASA) at 200 𝜇M was discharged 5.3, 7.1, and 8.1-fold higher into the apical site than into the basolateral site during 1, 2, and 4-hour incubations, respectively, in Caco-2 cells grown in Transwell...

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Bibliographic Details
Main Authors:	Shin Yoshimura, Kentaro Kawano, Ryusuke Matsumura, Narumi Sugihara, Koji Furuno
Format:	Article
Language:	English
Published:	Hindawi Limited 2009-01-01
Series:	Journal of Biomedicine and Biotechnology
Online Access:	http://dx.doi.org/10.1155/2009/467489

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