THREE-DIMENSIONAL MAPPING OF DIFFERENTIAL AMINO ACIDS OF HUMAN, MURINE, CANINE AND EQUINE TLR4/MD-2 RECEPTOR COMPLEXES CONFERRING ENDOTOXIC ACTIVATION BY LIPID A, ANTAGONISM BY ERITORAN AND SPECIES-DEPENDENT ACTIVITIES OF LIPID IVA IN THE MAMMALIAN LPS SENSOR SYSTEM

THREE-DIMENSIONAL MAPPING OF DIFFERENTIAL AMINO ACIDS OF HUMAN, MURINE, CANINE AND EQUINE TLR4/MD-2 RECEPTOR COMPLEXES CONFERRING ENDOTOXIC ACTIVATION BY LIPID A, ANTAGONISM BY ERITORAN AND SPECIES-DEPENDENT ACTIVITIES OF LIPID IVA IN THE MAMMALIAN LPS SENSOR SYSTEM

A literature review concerning the unexpected species differences of the vertebrate innate immune response to lipid IVA was published in CSBJ prior to the present computational study to address the unpaired activity-sequence correlation of prototypic E. coli -type lipid A and its precursor lipid IVA...

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Bibliographic Details
Main Authors: Thomas Scior, Jorge Lozano-Aponte, Vianihuini Figueroa-Vazquez, Julian A. Yunes-Rojas, Ulrich Zähringer, Christian Alexander
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Toll-like receptors
MD-2
lipopolysaccharide
molecular modeling
docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014600234

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