APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication.

APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication.

APOBEC3G (A3G)/APOBEC3F (A3F) are two members of APOBEC3 cytidine deaminase subfamily. Although they potently inhibit the replication of vif-deficient HIV-1, this mechanism is still poorly understood. Initially, A3G/A3F were thought to catalyze C-to-U transitions on the minus-strand viral cDNAs duri...

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Bibliographic Details
Main Authors: Yanxing Han, Xiaojun Wang, Ying Dang, Yong-Hui Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2435275?pdf=render

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