Aging Mechanisms: Linking oxidative stress, obesity and inflammation

• Main Authors: Ghazanfar Abbas, Amber Salman, Sajjad Ur Rahman, M. Khalil Ateeq, M. Usman, Sanaullah Sajid, Zaytoon Zaheer, Tayyaba Younas
• Format: Article
• Language: English
• Published: Zibeline International 2017-02-01
• Series: Matrix Science Medica
• Subjects: aging; reactive oxygen species; telomeres; obesity; inflammaging
• Online Access: https://matrixscmedica.com/archives/1msm2017/1msm2017-30-33.pdf
• ISSN: 2521-0807; 2521-0424

Aging cannot be defeated in anyway in the world even having new and advanced technology. But molecular mechanism is a successful method to control aging. Many complex and multifunctional factors are the main cause of aging. It is evident that the studies regarding cellular, genetic, and pathological and biochemical changes are exploring more and more pathways linking various diverse mechanism explaining aging. Implications of basic mechanisms of aging for improving both longevity and quality of life in human needs a clear understanding and takes a long time. However, reactive oxygen species (ROS) indicate a growing body even in the presence of fundamental mechanisms. According to oxidative stress theory, advanced and permanent addition of oxidative damage on critical aspects of aging process instigated by ROS influences. Telomeres theory is another, new aging theory that holds many promising possibilities for the field of anti-aging medicine. The theory was originated from the surge of technological breakthroughs in genetics and genetic engineering. Telomeres have also been found related to obesity. Obesity also leads to accelerated cellular processes. A “causative agent in aging” is considered inflammation that underlies a mechanism showing that for survival acute inflammatory response is necessary but long term exposure to different antigens than predicted by evolution cause low-grade inflammatory status which intern contributes to age-associated illness and death. The condition known as “inflammaging”.