Exploiting the Prevalence of Homologous Recombination Deficiencies in High-Grade Serous Ovarian Cancer

Exploiting the Prevalence of Homologous Recombination Deficiencies in High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecologic cancer in the United States. Genomic analysis revealed roughly half of HGSOC display homologous repair deficiencies. An improved understanding of the genomic and somatic mutations that influence DNA repair led to the develo...

Full description

Bibliographic Details
Main Authors: Sara Bouberhan, Lauren Philp, Sarah Hill, Linah F Al-Alem, Bo Rueda
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
homologous repair deficiency
BRCA
ovarian cancer
PARP
resistance
Online Access:https://www.mdpi.com/2072-6694/12/5/1206

Similar Items

Similar Items