Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability

Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability

Obesity is characterized by an excessive body mass, but is also closely associated with metabolic syndrome. And, so far, only limited pharmacological treatments are available for obesity management. Celastrol, a pentacyclic triterpenoid from a traditional Chinese medicine (Tripterygium wilfordii Hoo...

Full description

Bibliographic Details
Main Authors:	Bo Zhou, Yaxia Yuan, Le Shi, Sheng Hu, Dong Wang, Yang Yang, Yuanhu Pan, Dexin Kong, Alexander N. Shikov, Pierre Duez, Moonsoo Jin, Xiaohua Li, Xuebo Hu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Pharmacology
Subjects:	natural products obesity celastrol Glycyrrhiza uralensis glycyrrhetinic acid inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.705252/full

Similar Items

The anti-inflammatory activity of licorice, a widely used Chinese herb
by: Rui Yang, et al.
Published: (2017-01-01)

GuUGT, a glycosyltransferase from Glycyrrhiza uralensis, exhibits glycyrrhetinic acid 3- and 30-O-glycosylation
by: Ying Huang, et al.
Published: (2019-10-01)

Anti-rotaviral effects of <it>Glycyrrhiza uralensis</it> extract in piglets with rotavirus diarrhea
by: Alfajaro Mia Madel, et al.
Published: (2012-12-01)

Constituents Isolated from the Leaves of <i>Glycyrrhiza uralansis</i> and Their Anti-Inflammatory Activities on LPS-Induced RAW264.7 Cells
by: Liyao Wang, et al.
Published: (2019-05-01)

Tissue Culture and Micropropagation of Mongolian Licorice ( Glycyrrhiza uralensis Fisch.)
by: Yu. Oyunbileg, et al.
Published: (2005-06-01)

Improving the accumulation of 18α-and 18β-glycyrrhizins by over-expressing GuHMGR, GuSQS1, and GuBAS genes in Glycyrrhiza uralensis
by: Rui Yang, et al.
Published: (2017-10-01)

Extraction of Glycyrrhizic Acid from Glycyrrhiza uralensis Using Ultrasound and Its Process Extraction Model
by: Jiangqing Liao, et al.
Published: (2016-10-01)

Prenylated Flavonoids from Roots of Glycyrrhiza uralensis Induce Differentiation of B16-F10 Melanoma Cells
by: Yunfeng Zheng, et al.
Published: (2018-08-01)

Isolation and Characterization of Compounds from <i>Glycyrrhiza uralensis</i> as Therapeutic Agents for the Muscle Disorders
by: Eun Ju Lee, et al.
Published: (2021-01-01)

Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao
by: Yancao Mao, et al.
Published: (2017-09-01)

Effect of Abscisic Acid on Accumulation of Five Active Components in Root of Glycyrrhiza uralensis
by: Jing Qiao, et al.
Published: (2017-11-01)

Identification of the high-yield monacolin K strain from Monascus spp. and its submerged fermentation using different medicinal plants
by: Chen, F.-F, et al.
Published: (2022)

Potential biocontrol and plant growth promotion of an endophytic bacteria isolated from Glycyrrhiza uralensis seeds
by: Lang, D., et al.
Published: (2022)

A Analytical Review on Methods for the Isolation and Determination of Glycyrrhizic Acid from Glycyrrhiza glabra
by: M Khanahmadi, et al.
Published: (2014-05-01)

Glomus mosseae Inoculation Improves the Root System Architecture, Photosynthetic Efficiency and Flavonoids Accumulation of Liquorice under Nutrient Stress
by: Meilan Chen, et al.
Published: (2017-06-01)

Celastrol alleviates arthritis by modulating the inflammatory activities of neutrophils
by: Kai Yuan, et al.
Published: (2017-01-01)

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
by: Jinfeng Shi, et al.
Published: (2020-11-01)

Total Flavonoids of Glycyrrhiza uralensis Alleviates Irinotecan-Induced Colitis via Modification of Gut Microbiota and Fecal Metabolism
by: Shi-Jun Yue, et al.
Published: (2021-05-01)

Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from <i>Glycyrrhiza uralensis</i>
by: Geum Seok Jeong, et al.
Published: (2020-08-01)

The immunostimulatory activity of polysaccharides from Glycyrrhiza uralensis
by: Adila Aipire, et al.
Published: (2020-01-01)

Ultra-Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS)-Based Pharmacokinetics and Tissue Distribution Study of Koumine and the Detoxification Mechanism of Glycyrrhiza uralensis Fisch on Gelsemium elegans Benth.
by: Lin Wang, et al.
Published: (2018-07-01)

In vitro anthelmintic activity of an aqueous extract of Glycyrrhiza glabra and of glycyrrhetinic acid against gastrointestinal nematodes of small ruminants
by: Maestrini Michela, et al.
Published: (2021-01-01)

Synthesis and characterisation of celastrol derivatives as potential anticancer agents
by: Hong-Jian Zhang, et al.
Published: (2018-01-01)

Celastrol Niosome Hydrogel Has Anti-Inflammatory Effect on Skin Keratinocytes and Circulation without Systemic Drug Exposure in Psoriasis Mice
by: Qiu F, et al.
Published: (2021-09-01)

Celastrol Self-Stabilized Nanoparticles for Effective Treatment of Melanoma
by: Li J, et al.
Published: (2020-02-01)

Structures of New Phenolics Isolated from Licorice, and the Effectiveness of Licorice Phenolics on Vancomycin-Resistant Enterococci
by: Eerdunbayaer, et al.
Published: (2014-08-01)

Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species
by: Eerdunbayaer, et al.
Published: (2014-03-01)

Immune Responses of Asian Seabass <i>Lates calcarifer</i> to Dietary <i>Glycyrrhiza uralensis</i>
by: Rui Yang, et al.
Published: (2020-09-01)

Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro
by: Zou YC, et al.
Published: (2016-03-01)

Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
by: Rita Cascão, et al.
Published: (2017-06-01)

Growth-promoting bacteria alleviates drought stress of G. uralensis through improving photosynthesis characteristics and water status
by: Wenjin Zhang, et al.
Published: (2019-01-01)

Cloning and characterization of the gene encoding β-amyrin synthase in the glycyrrhizic acid biosynthetic pathway in Glycyrrhiza uralensis
by: Honghao Chen, et al.
Published: (2013-12-01)

Heat Treatment Improves UV Photoprotective Effects of Licorice in Human Dermal Fibroblasts
by: Jeong-Yong Park, et al.
Published: (2021-06-01)

HPLC DETERMINATION OF D-PANTHENOL AND GLYCYRRHETINIC ACID FROM A HERBAL ANTI-HERPETIC SUPPLEMENT
by: Elena Gabriela Oltean, et al.
Published: (2016-12-01)

Nanotechnology-Based Celastrol Formulations and Their Therapeutic Applications
by: Pushkaraj Rajendra Wagh, et al.
Published: (2021-06-01)

Celastrol Attenuates Inflammatory and Neuropathic Pain Mediated by Cannabinoid Receptor Type 2
by: Longhe Yang, et al.
Published: (2014-08-01)

Celastrol Inhibits Dopaminergic Neuronal Death of Parkinson’s Disease through Activating Mitophagy
by: Ming-Wei Lin, et al.
Published: (2019-12-01)

Formulation and Evaluation of Celastrol-Loaded Liposomes
by: Luyong Zhang, et al.
Published: (2011-09-01)

Antimicrobial Effects against Oral Pathogens and Cytotoxicity of <i>Glycyrrhiza uralensis</i> Extract
by: Song-Yi Yang, et al.
Published: (2020-07-01)

Celastrol nanomicelles attenuate cytokine secretion in macrophages and inhibit macrophage-induced corneal neovascularization in rats
by: Li Z, et al.
Published: (2016-11-01)