Development of a Bispecific Antibody-Based Platform for Retargeting of Capsid Modified AAV Vectors

Development of a Bispecific Antibody-Based Platform for Retargeting of Capsid Modified AAV Vectors

A major limiting factor for systemically delivered gene therapies is the lack of novel tissue specific AAV (Adeno-associated virus) derived vectors. Bispecific antibodies can be used to redirect AAVs to specific target receptors. Here, we demonstrate that the insertion of a short linear epitope “2E3...

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Bibliographic Details
Main Authors: Juliane Kuklik, Stefan Michelfelder, Felix Schiele, Sebastian Kreuz, Thorsten Lamla, Philipp Müller, John E. Park
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
adeno-associated viral vectors
AAV
protein engineering
retargeting
bispecific antibody
capsid modification
Online Access:https://www.mdpi.com/1422-0067/22/15/8355

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