Role of m<sup>6</sup>A in Embryonic Stem Cell Differentiation and in Gametogenesis

Role of m<sup>6</sup>A in Embryonic Stem Cell Differentiation and in Gametogenesis

The rising field of RNA modifications is stimulating massive research nowadays. m<sup>6</sup>A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classifie...

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Main Authors: Lior Lasman, Jacob H Hanna, Noa Novershtern
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Epigenomes
Subjects:
rna modification
<i>n</i><sup>6</sup>-methyladenosine
m<sup>6</sup>a
stem cells
spermatogenesis
oogenesis
Online Access:https://www.mdpi.com/2075-4655/4/1/5
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spelling doaj-27e8c06be80d43dcbdc4016ba03cad6d2021-04-02T08:56:31ZengMDPI AGEpigenomes2075-46552020-03-0141510.3390/epigenomes4010005epigenomes4010005Role of m<sup>6</sup>A in Embryonic Stem Cell Differentiation and in GametogenesisLior Lasman0Jacob H Hanna1Noa Novershtern2The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, IsraelThe Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, IsraelThe Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, IsraelThe rising field of RNA modifications is stimulating massive research nowadays. m<sup>6</sup>A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classified into writer, eraser and reader proteins. m<sup>6</sup>A modification is now known to take part in diverse biological processes such as embryonic development, cell circadian rhythms and cancer stem cell proliferation. In addition, there is already firm evidence for the importance of m<sup>6</sup>A modification in stem cell differentiation and gametogenesis, both in males and females. This review attempts to summarize the important results of recent years studying the mechanism underlying stem cell differentiation and gametogenesis processes.https://www.mdpi.com/2075-4655/4/1/5rna modification<i>n</i><sup>6</sup>-methyladenosinem<sup>6</sup>astem cellsspermatogenesisoogenesis
collection DOAJ
language English
format Article
sources DOAJ
author Lior Lasman
Jacob H Hanna
Noa Novershtern
spellingShingle Lior Lasman
Jacob H Hanna
Noa Novershtern
Role of m<sup>6</sup>A in Embryonic Stem Cell Differentiation and in Gametogenesis
Epigenomes
rna modification
<i>n</i><sup>6</sup>-methyladenosine
m<sup>6</sup>a
stem cells
spermatogenesis
oogenesis
author_facet Lior Lasman
Jacob H Hanna
Noa Novershtern
author_sort Lior Lasman
title Role of m<sup>6</sup>A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_short Role of m<sup>6</sup>A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_full Role of m<sup>6</sup>A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_fullStr Role of m<sup>6</sup>A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_full_unstemmed Role of m<sup>6</sup>A in Embryonic Stem Cell Differentiation and in Gametogenesis
title_sort role of m<sup>6</sup>a in embryonic stem cell differentiation and in gametogenesis
publisher MDPI AG
series Epigenomes
issn 2075-4655
publishDate 2020-03-01
description The rising field of RNA modifications is stimulating massive research nowadays. m<sup>6</sup>A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classified into writer, eraser and reader proteins. m<sup>6</sup>A modification is now known to take part in diverse biological processes such as embryonic development, cell circadian rhythms and cancer stem cell proliferation. In addition, there is already firm evidence for the importance of m<sup>6</sup>A modification in stem cell differentiation and gametogenesis, both in males and females. This review attempts to summarize the important results of recent years studying the mechanism underlying stem cell differentiation and gametogenesis processes.
topic rna modification
<i>n</i><sup>6</sup>-methyladenosine
m<sup>6</sup>a
stem cells
spermatogenesis
oogenesis
url https://www.mdpi.com/2075-4655/4/1/5
work_keys_str_mv AT liorlasman roleofmsup6supainembryonicstemcelldifferentiationandingametogenesis
AT jacobhhanna roleofmsup6supainembryonicstemcelldifferentiationandingametogenesis
AT noanovershtern roleofmsup6supainembryonicstemcelldifferentiationandingametogenesis
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