The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways

The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways

Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking. Rab proteins alternate between an activated (GTP-bound) state and an inactivated (GDP-bound) state. Early endosome marker Rab5 G...

Full description

Bibliographic Details
Main Authors: Wanqiong Yuan, Chunli Song
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Biochemistry Research International
Online Access:http://dx.doi.org/10.1155/2020/4186308
id doaj-27e383d235df47cbb5267b5522a5e9e1
record_format Article
spelling doaj-27e383d235df47cbb5267b5522a5e9e12020-11-25T02:39:51ZengHindawi LimitedBiochemistry Research International2090-22472090-22552020-01-01202010.1155/2020/41863084186308The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling PathwaysWanqiong Yuan0Chunli Song1Department of Orthopedics, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 100191, ChinaDepartment of Orthopedics, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 100191, ChinaRas analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking. Rab proteins alternate between an activated (GTP-bound) state and an inactivated (GDP-bound) state. Early endosome marker Rab5 GTPase, a key member of the Rab family, plays a crucial role in endocytosis and membrane transport. The activated-state Rab5 recruits its effectors and regulates the internalization and trafficking of membrane receptors by regulating vesicle fusion and receptor sorting in the early endosomes. In this review, we summarize the role of small Rab GTPases Rab5 in membrane receptor trafficking and the activation of signaling pathways, such as Ras/MAPK and PI3K/Akt, which ultimately affect cell growth, apoptosis, tumorigenesis, and tumor development. This review may provide some insights for our future research and novel therapeutic targets for diseases.http://dx.doi.org/10.1155/2020/4186308
collection DOAJ
language English
format Article
sources DOAJ
author Wanqiong Yuan
Chunli Song
spellingShingle Wanqiong Yuan
Chunli Song
The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
Biochemistry Research International
author_facet Wanqiong Yuan
Chunli Song
author_sort Wanqiong Yuan
title The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
title_short The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
title_full The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
title_fullStr The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
title_full_unstemmed The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
title_sort emerging role of rab5 in membrane receptor trafficking and signaling pathways
publisher Hindawi Limited
series Biochemistry Research International
issn 2090-2247
2090-2255
publishDate 2020-01-01
description Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking. Rab proteins alternate between an activated (GTP-bound) state and an inactivated (GDP-bound) state. Early endosome marker Rab5 GTPase, a key member of the Rab family, plays a crucial role in endocytosis and membrane transport. The activated-state Rab5 recruits its effectors and regulates the internalization and trafficking of membrane receptors by regulating vesicle fusion and receptor sorting in the early endosomes. In this review, we summarize the role of small Rab GTPases Rab5 in membrane receptor trafficking and the activation of signaling pathways, such as Ras/MAPK and PI3K/Akt, which ultimately affect cell growth, apoptosis, tumorigenesis, and tumor development. This review may provide some insights for our future research and novel therapeutic targets for diseases.
url http://dx.doi.org/10.1155/2020/4186308
work_keys_str_mv AT wanqiongyuan theemergingroleofrab5inmembranereceptortraffickingandsignalingpathways
AT chunlisong theemergingroleofrab5inmembranereceptortraffickingandsignalingpathways
AT wanqiongyuan emergingroleofrab5inmembranereceptortraffickingandsignalingpathways
AT chunlisong emergingroleofrab5inmembranereceptortraffickingandsignalingpathways
_version_ 1715421309652959232

Similar Items