| Summary: | Medical image quality is highly relative to clinical diagnosis and treatment, leading to a popular research topic of medical image denoising. Image denoising based on deep learning methods has attracted considerable attention owing to its excellent ability of automatic feature extraction. Most existing methods for medical image denoising adapted to certain types of noise have difficulties in handling spatially varying noise; meanwhile, image detail losses and structure changes occurred in the denoised image. Considering image context perception and structure preserving, this paper firstly introduces a medical image denoising method based on conditional generative adversarial network (CGAN) for various unknown noises. In the proposed architecture, noise image with the corresponding gradient image is merged as network conditional information, which enhances the contrast between the original signal and noise according to the structural specificity. A novel generator with residual dense blocks makes full use of the relationship among convolutional layers to explore image context. Furthermore, the reconstruction loss and WGAN loss are combined as the objective loss function to ensure the consistency of denoised image and real image. A series of experiments for medical image denoising are conducted with the denoising results of PSNR=33.2642 and SSIM=0.9206 on JSRT datasets and PSNR=35.1086 and SSIM=0.9328 on LIDC datasets. Compared with the state-of-the-art methods, the superior performance of the proposed method is outstanding.
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