An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

The purpose of this study was to predict in vivo performance of three oral products of Etoricoxib (<i>Arcoxia</i><sup>®</sup> as reference and two generic formulations in development) by conducting in vivo predictive dissolution with GIS (Gastro Intestinal Simulator) and comp...

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Bibliographic Details
Main Authors: Isabel Gonzalez-Alvarez, Marival Bermejo, Yasuhiro Tsume, Alejandro Ruiz-Picazo, Marta Gonzalez-Alvarez, Bart Hens, Alfredo Garcia-Arieta, Greg E. Amidon, Gordon L. Amidon
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
gastrointestinal simulator
in vitro dissolution
BCS class II
weak base
dissolution modelling
Online Access:https://www.mdpi.com/1999-4923/13/4/507

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https://www.mdpi.com/1999-4923/13/4/507

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