Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus

Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus

Bisphenol A (BPA), an endocrine disruptor, exist in almost all waters. In the present study, we expose adult male Gobiocypris rarus rare minnow to 15 μg/L BPA to study the effect BPA on fish hepatic lipid metabolism. Following 1, 3 and 5 weeks exposure, the liver tissue of rare minnow was separated....

Full description

Bibliographic Details
Main Authors: Kaihang Mi, Xi Chen, Kaiyuan Lu, Yujie Zhu, Meng Zhang, Hui Yang, Wenzhi Wei, Yingying Zhang
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Bisphenol A
Liver
Lipid metabolism
Triglyceride
Gobiocypris rarus
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321001615
id doaj-27c1c7c155374580b8f506502efb4412
record_format Article
spelling doaj-27c1c7c155374580b8f506502efb44122021-04-23T06:16:34ZengElsevierEcotoxicology and Environmental Safety0147-65132021-04-01213112050Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarusKaihang Mi0Xi Chen1Kaiyuan Lu2Yujie Zhu3Meng Zhang4Hui Yang5Wenzhi Wei6Yingying Zhang7College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCorresponding author.; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaBisphenol A (BPA), an endocrine disruptor, exist in almost all waters. In the present study, we expose adult male Gobiocypris rarus rare minnow to 15 μg/L BPA to study the effect BPA on fish hepatic lipid metabolism. Following 1, 3 and 5 weeks exposure, the liver tissue of rare minnow was separated. The change of the hepatic morphology, hepatosomatic index, lipid composition and expression of lipid metabolism related genes were analyzed through paraffin section, oil red O staining, lipidomic analysis, and quantitative real-time PCR. BPA can cause significant hepatic lipid deposition in male rare minnow, leading to an increase in triglyceride (TG) level (1.84–22.87-fold), but it is also accompanied by a decrease in diglyceride level (1.67–4.78-fold). The expression of lipid metabolism related genes showed that BPA exposure can up-regulate TG synthesis related genes expression, and down-regulate TG degradation genes expression. Expression of TG transport related genes were also disrupted by BPA. It suggests that BPA can up-regulate rare minnow hepatic TG level through multi-path, and ultimately lead to lipid accumulation in the liver. The results of the present study enrich the mechanisms of environmental endocrine disruptors affecting lipid accumulation in fish.http://www.sciencedirect.com/science/article/pii/S0147651321001615Bisphenol ALiverLipid metabolismTriglycerideGobiocypris rarus
collection DOAJ
language English
format Article
sources DOAJ
author Kaihang Mi
Xi Chen
Kaiyuan Lu
Yujie Zhu
Meng Zhang
Hui Yang
Wenzhi Wei
Yingying Zhang
spellingShingle Kaihang Mi
Xi Chen
Kaiyuan Lu
Yujie Zhu
Meng Zhang
Hui Yang
Wenzhi Wei
Yingying Zhang
Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus
Ecotoxicology and Environmental Safety
Bisphenol A
Liver
Lipid metabolism
Triglyceride
Gobiocypris rarus
author_facet Kaihang Mi
Xi Chen
Kaiyuan Lu
Yujie Zhu
Meng Zhang
Hui Yang
Wenzhi Wei
Yingying Zhang
author_sort Kaihang Mi
title Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus
title_short Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus
title_full Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus
title_fullStr Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus
title_full_unstemmed Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus
title_sort bisphenol a induces hepatic triglyceride level in adult male rare minnow gobiocypris rarus
publisher Elsevier
series Ecotoxicology and Environmental Safety
issn 0147-6513
publishDate 2021-04-01
description Bisphenol A (BPA), an endocrine disruptor, exist in almost all waters. In the present study, we expose adult male Gobiocypris rarus rare minnow to 15 μg/L BPA to study the effect BPA on fish hepatic lipid metabolism. Following 1, 3 and 5 weeks exposure, the liver tissue of rare minnow was separated. The change of the hepatic morphology, hepatosomatic index, lipid composition and expression of lipid metabolism related genes were analyzed through paraffin section, oil red O staining, lipidomic analysis, and quantitative real-time PCR. BPA can cause significant hepatic lipid deposition in male rare minnow, leading to an increase in triglyceride (TG) level (1.84–22.87-fold), but it is also accompanied by a decrease in diglyceride level (1.67–4.78-fold). The expression of lipid metabolism related genes showed that BPA exposure can up-regulate TG synthesis related genes expression, and down-regulate TG degradation genes expression. Expression of TG transport related genes were also disrupted by BPA. It suggests that BPA can up-regulate rare minnow hepatic TG level through multi-path, and ultimately lead to lipid accumulation in the liver. The results of the present study enrich the mechanisms of environmental endocrine disruptors affecting lipid accumulation in fish.
topic Bisphenol A
Liver
Lipid metabolism
Triglyceride
Gobiocypris rarus
url http://www.sciencedirect.com/science/article/pii/S0147651321001615
work_keys_str_mv AT kaihangmi bisphenolainduceshepatictriglyceridelevelinadultmalerareminnowgobiocyprisrarus
AT xichen bisphenolainduceshepatictriglyceridelevelinadultmalerareminnowgobiocyprisrarus
AT kaiyuanlu bisphenolainduceshepatictriglyceridelevelinadultmalerareminnowgobiocyprisrarus
AT yujiezhu bisphenolainduceshepatictriglyceridelevelinadultmalerareminnowgobiocyprisrarus
AT mengzhang bisphenolainduceshepatictriglyceridelevelinadultmalerareminnowgobiocyprisrarus
AT huiyang bisphenolainduceshepatictriglyceridelevelinadultmalerareminnowgobiocyprisrarus
AT wenzhiwei bisphenolainduceshepatictriglyceridelevelinadultmalerareminnowgobiocyprisrarus
AT yingyingzhang bisphenolainduceshepatictriglyceridelevelinadultmalerareminnowgobiocyprisrarus
_version_ 1721512968992063488

Similar Items