Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.

Bibliographic Details
Main Authors:	Ilya G. Serebriiskii, Caitlin Connelly, Garrett Frampton, Justin Newberg, Matthew Cooke, Vince Miller, Siraj Ali, Jeffrey S. Ross, Elizabeth Handorf, Sanjeevani Arora, Christopher Lieu, Erica A. Golemis, Joshua E. Meyer
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11530-0

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spelling	doaj-27bc5c9b4b90416a81f526fbc7b0c8ee2021-05-11T12:32:47ZengNature Publishing GroupNature Communications2041-17232019-08-0110111210.1038/s41467-019-11530-0Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patientsIlya G. Serebriiskii0Caitlin Connelly1Garrett Frampton2Justin Newberg3Matthew Cooke4Vince Miller5Siraj Ali6Jeffrey S. Ross7Elizabeth Handorf8Sanjeevani Arora9Christopher Lieu10Erica A. Golemis11Joshua E. Meyer12Program in Molecular Therapeutics, Fox Chase Cancer CenterFoundation Medicine Inc.Foundation Medicine Inc.Foundation Medicine Inc.Foundation Medicine Inc.Foundation Medicine Inc.Foundation Medicine Inc.Foundation Medicine Inc.Bioinformatics and Biostatistics Facility, Fox Chase Cancer CenterProgram in Cancer Prevention and Control, Fox Chase Cancer CenterDivision of Medical Oncology, University of Colorado Cancer CenterProgram in Molecular Therapeutics, Fox Chase Cancer CenterProgram in Molecular Therapeutics, Fox Chase Cancer CenterActivating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.https://doi.org/10.1038/s41467-019-11530-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ilya G. Serebriiskii Caitlin Connelly Garrett Frampton Justin Newberg Matthew Cooke Vince Miller Siraj Ali Jeffrey S. Ross Elizabeth Handorf Sanjeevani Arora Christopher Lieu Erica A. Golemis Joshua E. Meyer
spellingShingle	Ilya G. Serebriiskii Caitlin Connelly Garrett Frampton Justin Newberg Matthew Cooke Vince Miller Siraj Ali Jeffrey S. Ross Elizabeth Handorf Sanjeevani Arora Christopher Lieu Erica A. Golemis Joshua E. Meyer Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients Nature Communications
author_facet	Ilya G. Serebriiskii Caitlin Connelly Garrett Frampton Justin Newberg Matthew Cooke Vince Miller Siraj Ali Jeffrey S. Ross Elizabeth Handorf Sanjeevani Arora Christopher Lieu Erica A. Golemis Joshua E. Meyer
author_sort	Ilya G. Serebriiskii
title	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_short	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_full	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_fullStr	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_full_unstemmed	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
title_sort	comprehensive characterization of ras mutations in colon and rectal cancers in old and young patients
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-08-01
description	Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.
url	https://doi.org/10.1038/s41467-019-11530-0
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Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

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