Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer.

Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer.

Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options. We previously found that PARP is overexpressed in SCLC and that targeting PARP reduces cell line and tumor growth in preclinical models. However, SCLC cell lines with PI3K/mTOR pathway activation were relativel...

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Bibliographic Details
Main Authors: Robert J Cardnell, Ying Feng, Seema Mukherjee, Lixia Diao, Pan Tong, C Allison Stewart, Fatemeh Masrorpour, YouHong Fan, Monique Nilsson, Yuqiao Shen, John V Heymach, Jing Wang, Lauren A Byers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4824499?pdf=render

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