Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor

Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor

Photodynamic therapy has attracted interest in treating cancer but it is limited in hypoxic tumors due to a lack of oxygen. Here, the authors describe a nano-composite capable of generating oxygen under near-infrared light for improved photodynamic and chemotherapy for treating cancer.

Bibliographic Details
Main Authors: Shuting Xu, Xinyuan Zhu, Chuan Zhang, Wei Huang, Yongfeng Zhou, Deyue Yan
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04318-1
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spelling doaj-27b1dfaf2446400886b0dcbf27ae69542021-05-11T09:58:16ZengNature Publishing GroupNature Communications2041-17232018-05-01911910.1038/s41467-018-04318-1Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumorShuting Xu0Xinyuan Zhu1Chuan Zhang2Wei Huang3Yongfeng Zhou4Deyue Yan5School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong UniversityPhotodynamic therapy has attracted interest in treating cancer but it is limited in hypoxic tumors due to a lack of oxygen. Here, the authors describe a nano-composite capable of generating oxygen under near-infrared light for improved photodynamic and chemotherapy for treating cancer.https://doi.org/10.1038/s41467-018-04318-1
collection DOAJ
language English
format Article
sources DOAJ
author Shuting Xu
Xinyuan Zhu
Chuan Zhang
Wei Huang
Yongfeng Zhou
Deyue Yan
spellingShingle Shuting Xu
Xinyuan Zhu
Chuan Zhang
Wei Huang
Yongfeng Zhou
Deyue Yan
Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
Nature Communications
author_facet Shuting Xu
Xinyuan Zhu
Chuan Zhang
Wei Huang
Yongfeng Zhou
Deyue Yan
author_sort Shuting Xu
title Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
title_short Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
title_full Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
title_fullStr Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
title_full_unstemmed Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
title_sort oxygen and pt(ii) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-05-01
description Photodynamic therapy has attracted interest in treating cancer but it is limited in hypoxic tumors due to a lack of oxygen. Here, the authors describe a nano-composite capable of generating oxygen under near-infrared light for improved photodynamic and chemotherapy for treating cancer.
url https://doi.org/10.1038/s41467-018-04318-1
work_keys_str_mv AT shutingxu oxygenandptiiselfgeneratingconjugateforsynergisticphotochemotherapyofhypoxictumor
AT xinyuanzhu oxygenandptiiselfgeneratingconjugateforsynergisticphotochemotherapyofhypoxictumor
AT chuanzhang oxygenandptiiselfgeneratingconjugateforsynergisticphotochemotherapyofhypoxictumor
AT weihuang oxygenandptiiselfgeneratingconjugateforsynergisticphotochemotherapyofhypoxictumor
AT yongfengzhou oxygenandptiiselfgeneratingconjugateforsynergisticphotochemotherapyofhypoxictumor
AT deyueyan oxygenandptiiselfgeneratingconjugateforsynergisticphotochemotherapyofhypoxictumor
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