Short Peptides with Uncleavable Peptide Bond Mimetics as Photoactivatable Caspase-3 Inhibitors

Short Peptides with Uncleavable Peptide Bond Mimetics as Photoactivatable Caspase-3 Inhibitors

Chemical probes that covalently interact with proteases have found increasing use for the study of protease function and localization. The design and synthesis of such probes is still a bottleneck, as the strategies to target different families are highly diverse. We set out to design and synthesize...

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Bibliographic Details
Main Authors: Tim Van Kersavond, Raphael Konopatzki, Suravi Chakrabarty, Bernhard Blank-Landeshammer, Albert Sickmann, Steven H. L. Verhelst
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
chemical probes
click chemistry
inhibitors
photocrosslinkers
photoactivation
proteases
triazoles
Online Access:http://www.mdpi.com/1420-3049/24/1/206

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