The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging

The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging

Mitochondrial activity determines aging rate and the onset of chronic diseases. The mitochondrial permeability transition pore (mPTP) is a pathological pore in the inner mitochondrial membrane thought to be composed of the F-ATP synthase (complex V). OSCP, a subunit of F-ATP synthase, helps protect...

Full description

Bibliographic Details
Main Authors: Suzanne Angeli, Anna Foulger, Manish Chamoli, Tanuja Harshani Peiris, Akos Gerencser, Azar Asadi Shahmirzadi, Julie Andersen, Gordon Lithgow
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
mitochondrial unfolded protein response
mitochondrial permeability transition pore
oscp/atp-3
c-subunit
aging
F-ATP synthase
Online Access:https://elifesciences.org/articles/63453

Internet

https://elifesciences.org/articles/63453

Similar Items