Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation
Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), but its clinical effects are still limited. In this study we identify Quiescin sulfhydryl oxidase 1 (QSOX1) acting as a cellular pro-oxidant, specifically in the context of sorafenib treatment of HCC. QSOX1...
Main Authors: | Jialei Sun, Chenhao Zhou, Yue Zhao, Xiaofei Zhang, Wanyong Chen, Qiang Zhou, Bo Hu, Dongmei Gao, Lisa Raatz, Zhefang Wang, Peter J. Nelson, Yuchao Jiang, Ning Ren, Christiane J. Bruns, Haijun Zhou |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-05-01
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Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231721000902 |
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